Chiara Graziadio Archivi

Anoressia nervosa: amenorrea ipotalamica e metabolismo dell’osso

Daniela Laudisio^1,2– , Chiara Graziadio^1,2– , Renata Simona Auriemma¹– , Emanuela Filice¹– , Silvia Savastano^1,2– , Annamaria Colao^1,2,3–

1 – Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università “Federico II” di Napoli, Napoli, Italia

2 – Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università “Federico II” di Napoli, Napoli, Italia

3 – Cattedra Unesco “Educazione alla salute e allo sviluppo sostenibile”,Università “Federico II” di Napoli, Napoli, Italia

Autore di riferimento: Daniela Laudisio

daniela.laudisio@libero.it

DOI: 10.53146/lriog1202154

Abstract

Anorexia nervosa is a psychiatric disorder, predominantly affecting adolescent women, and is characterized by a low body weight following a state of self-induced starvation. This disorder is associated with hormonal adaptations that consume energy expenditure to a minimum in a context of low nutrient intake. These adaptations include: functional hypothalamic amenorrhea, resistance to growth hormone, low concentrations of insulin- like growth factor, low concentrations of leptin and hypercortisolemia. Although, these adaptations may be useful for the short-term survival, often, they contribute to morbidity associated with this disorder, and in particular bone loss, which affects 85% of women with anorexia nervosa. In fact, this category of patients, often demonstrates low bone mineral density and high fractures risk, with low body weight and low gonads being the strongest predictors of observed bone mineral deficiency and fractures risk. Weight restoration and the resumption of menstrual function have the strongest impact on increasing bone mineral density. Other treatment options include bisphosphonates and teriparatide, supported by small clinical trials.

Keywords: nervous anorexia; functional hypothalamic amenorrhea; osteoporosis; bone mineral density; risk of fractures.

Presente in LRIOG Nr.1 – 2022

e-ISSN: 1824-0283

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Patologie tiroidee ed infertilità femminile

Chiara Graziadio^1,2– , Emanuele Filice¹– , Rosa Pirchio¹– , Renata Simona Auriemma¹– , Alessandra Graziottin³– ,

Annamaria Colao^1,2,4–

1 – Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi Federico II Napoli

2 – Centro Italiano per la cura ed il benessere del paziente obeso (C.I.B.O.), Università degli Studi Federico II Napoli

3 – Centro di Ginecologia H. San Raffaele Resnati, Milano

4 – Cattedra Unesco “Educazione alla salute e allo Sviluppo Sostenibile”, Università degli Studi Federico II Napoli

Autore di riferimento: Chiara Graziadio

chiaragraziadio@live.it

DOI: 10.53146/lriog1202152

Abstract

BACKGROUND: Thyroid diseases (hypothyroidism, hyperthyroidism and thyroid autoimmunity) have been independently associated with fertility di- sorders and pregnancy failure, both in case of spontaneous conception and/ or after assisted reproduction technology (ART). Several studies have looked at the association between thyroid dysfunctions, thyroid autoimmunity (TAI) and reproduction. The aim of this paper is to identify the impact of thyroid diseases, starting from birth, on female infertility, by means of review of the recent pertinent literature.
METHODS: We reviewed the pertinent literature regarding the association between thyroid diseases and female infertility off the main international database (MEDLINE, PubMed).
RESULTS: Thyroid dysfunctions, associated or not with thyroid autoimmunity, can alter ovulation and the associated immunoendocrine processes with con- sequent menstrual irregularities. These complexes endocrine disruptions can result in mild to severe fertility disorders and increased spontaneous abor- tions. Thyroid autoimmunity is associated with an increased risk of miscar- riage and preterm delivery, both in spontaneous pregnancies as well as in pregnancies after ART.
CONCLUSIONS: Thyroid dysfunctions may lead to menstrual disorders and infertility via direct and indirect interactions with the hypothalamo-pituitary- ovarian axis and the reproductive organs.
In the management of the infertile woman, the complete screening of thyroid hormones and autoimmunity is recommended in order to promptly treat any hormonal dysfunctions that may be a cofactor or the cause of infertility. Fur- ther studies are needed to improve diagnostic and therapeutic fertility issues associated with or due to thyroid disorders.

Keywords: hashimoto’s thyroiditis; Basedow-Graves’disease; hyperthyroidism; hypothyroidism; female infertility; thyroid autoimmunity.

Presente in LRIOG Nr.4 – 2021

e-ISSN: 1824-0283

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