The vagina: therapeutic role of ospemifene

The Genitourinary Syndrome of Menopause (GSM) is a progressive chronic condition that can be very bothersome for women. This disease, mainly due to the endocrinological changes occurring with menopause, is characterized by symptoms such as vaginal dryness, dyspareunia, itching, burning and dysuria. The marketing of a relatively new drug, Ospemifene, for the treatment of this clinical condition has given a new therapeutic option and prospective for a better quality of life in women affected by VulvoVaginal Atrophia (VVA). Ospemifene is a Selective Estrogen Receptor Modulator (SERM) and can also be prescibed to women with a history of breast cancer. The oral route of administration has shown to give higher adherence to treatment being preferable for many women to the vaginal route with a high satisfaction rate. In this article the main characteristics of the effects of Ospemifene on GSM have been elucidated and some of the most interesting studies have been illustrated. Women’s wording has been reported and particular attention given to their personal and familiar histories. Objective vulvar examination is described and aspects to be analysed in deep are reported. Therapeutic suggestions of a multimodal approach to the disease are made, although on this matter further scientific studies showing solid data are needed.