The vagina, oncological target: Vain and therapeutic strategies

The vagina, oncological target: Vain and therapeutic strategies

Francesco Sopracordevole1 – Orcid , Nicolò Clemente1 – Orcid, Anna del Fabro1 – Orcid

1 – SOC of Oncological Gynecology – Oncological Reference Center of Aviano – IRCCS

Corresponding author: Francesco Sopracordevole

DOI: 10.53146/lriog1202120


VaIN (Vaginal Intraepithelial Neoplasia) is a challenge disease for gynecologists: it is often undiagnosed, difficult to treat, with high rate of recurrence and, in some cases, it can progress to invasive vaginal cancer. Multiple treatments are often required, with a potential impairment of women’s quality of life. To get a proper diagnosis and adequate treatment, all the women with abnormal pap smear, should undergo an accurate colposcopic evaluation of vaginal walls. A colposcopy-guided biopsy of suspicious lesions is mandatory. The treatment of VaIN (especially the most complex cases) should be performed by expert colposcopists in referral centres.

Keywords: VaIN; vaginal intraepithelial neoplasia; pap smear; vaginal excision; vaginal surgery.

Available in LRIOG Nr.2 – 2021

e-ISSN: 1824-0283

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Extrammamary Paget’s disease of the vulva (EMPDV)

Extrammamary Paget’s disease of the vulva (EMPDV), this unknown

Francesco Sopracordevole1 – Orcid, Nicolò Clemente1 – Orcid, Anna del Fabro– Orcid

1 – CRO (Centro di Riferimento Oncologico – Oncological Reference Centre)  Cancer Institute Aviano

Corresponding author: Francesco Sopracordevole

DOI: 10.53146/lriog120214


Extramammary Paget’s disease of the vulva (EMPDv) is a rare neoplasia, with only intraepithelial spread in most of the cases, slowly evolving, with aspecific symptoms and high recurrence rate.
Extensive surgery is often necessary with repeated excision in case of recurrent disease. This can lead to significant genital disfigurement and impairment of the quality of life. Less invasive treatments (radiotherapy, immunotherapy, photodynamic therapy, laser ablation) have variable response and high recurrence rate. In case of invasive disease, poorly responsive to radio/chemotherapy, if a HER2 overexpression is detected, excisional surgery followed by specific target therapy is showing promising results. The key factor for the optimal management of EMPDv is the prompt diagnosis and treatment of lesions, in a multidisciplinary approach with proper therapies and a long-term follow-up, preserving the patient’s genital function and self-image.

Keywords: vulvar extramammary paget’s disease; surgery; diagnosis.

Available in LRIOG Nr.1 – 2021

e-ISSN: 1824-0283

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